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Updated: Jul 5, 2025

Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist
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对T细胞信号通路的光学传感和控制

Hae Nim Lee1,2, Seung Eun Lee3, Kyung-Soo Inn2

  • 1Brain Science Institute, Korea Institute of Science and Technoloy, Seoul, Republic of Korea.

Frontiers in physiology
|January 25, 2024
PubMed
概括

新的生物传感器和光遗传工具为T细胞受体 (TCR) 和仿真抗原受体 (CAR) T细胞信号传递动态提供了先进的见解. 这些技术克服了研究复杂免疫反应的传统方法的局限性.

关键词:
在CART-T中,我们可以使用CAR-T.费特·弗雷特 (FRET FRET) 是一家在美国的船只.T细胞受体受体的 T 细胞受体.基因编码的光生物传感器视觉遗传学 视觉遗传学

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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