在米托坦治疗下受上腺皮癌影响的男性中,低雄性和性功能
Letizia Canu1,2,3,4, Clotilde Sparano1,2, Lara Naletto1
1Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.
Frontiers in endocrinology
|January 25, 2024
概括
对上腺皮层癌的辅助性米托坦疗法会导致低体和勃起功能障碍. 雄激素替代疗法改善了受影响的男性患者的丸激素水平和性功能.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 性医学性医学性医学性医学
背景情况:
- 皮上腺癌 (ACC) 是一种罕见的,激进的恶性瘤.
- 接受辅助性米托坦疗法 (AMT) 的男性ACC患者往往会发展为阴性双胞胎症.
- 这一患者群的性功能仍未得到充分研究.
研究的目的:
- 为了评估AMT的ACC患者的荷尔蒙变化 (LH,SHBG,TT,cFT).
- 为了确定下性和性功能障碍的患病率和类型.
- 评估雄激素替代疗法 (ART) 对性功能的影响.
主要方法:
- 在18个月的AMT中,对10名ACC患者的激素水平 (LH,SHBG,TT,cFT) 的回顾性分析.
- 在8名阴阴腺患者中,在ART前后评估阴阴腺症和性功能 (IIEF-15).
- 在AMT和ART期间,在基线和多个时间点测量了荷尔蒙水平.
主要成果:
- AMT与SHBG和LH升高,cFT降低有关.
- 在18个月后,80%的患者患有过高性热性性腺症,83.3%患有勃起功能障碍 (ED).
- ART显著增加了cFT和改善了IIEF-15分数,将ED患病率降低到16.7%.
结论:
- 在ACC患者中,AMT有助于高性腺和ED.
- ART有效地改善丸激素水平和性功能在低腺ACC患者.
- 建议在AMT期间定期监测荷尔蒙和性功能,并及时启动ART治疗功能障碍.
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