在从拉坦诺普罗斯特0.005%转换为拉坦诺普罗斯布诺德0.024后,眼睛表面评估
Virginia Zanutigh1, Leila Galetto1, Florencia Valvecchia2
1Department of Glaucoma, Centro de Ojos Quilmes, Quilmes, Buenos Aires, Argentina.
Journal of current glaucoma practice
|January 25, 2024
概括
从latanoprost (LT) 转换为latanoprostene bunod (LBN) 改善了青光眼患者的眼表面疾病指数得分. LBN治疗维持了眼内压力控制,并显示了潜在的眼皮表面益处.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 眼睛表面疾病 眼睛表面疾病
背景情况:
- 慢性开角玻璃眼患者在前列腺素类比治疗时经常出现眼睛表面问题.
- 拉坦诺 (LT) 0.005%是一种常见的治疗方法,但切换到像拉坦诺布诺德 (LBN) 0.024%这样的新药可能会有好处.
研究的目的:
- 为了评估从0.005%的拉坦诺普罗斯特 (LT) 转换为0.024%的拉坦诺普罗斯布诺德 (LBN) 对青光眼患者眼睛表面的影响.
- 评估眼皮表面疾病指数 (OSDI),眼内压力 (IOP) 和其他眼皮表面参数的变化.
主要方法:
- 一项前性非随机临床研究包括36名以前用LT治疗过的慢性开角玻璃眼患者.
- 患者在洗期后转换为LBN,随着3个月的随访.
- 评估的参数包括OSDI,最佳校正视敏度 (BCVA),IOP,眼破裂时间,光素染色和施密尔I测试.
主要成果:
- OSDI得分从17.8显著提高到11.1 (p < 0.01).
- 光素染色显示改善 (牛津尺度0.6到0.2,p=0.01),而眼破裂时间和希尔默测试结果没有显著变化.
- 在整个研究期间,BCVA和IOP保持稳定.
结论:
- 从0.005%的拉坦诺普罗斯特 (LT) 转换为0.024%的拉坦诺普罗斯布诺德 (LBN) 改善了玻璃眼患者的眼表面症状和迹象.
- 在保持IOP控制的同时,LBN证明了对眼睛表面的潜在有益影响.
- 进一步研究LBN对眼睛表面效益的机制,可能与氧化有关,是有必要的.
关键词:
眼光障碍 眼光障碍 眼光障碍 眼光障碍拉塔诺普罗斯特是一种拉塔诺普罗斯特拉塔诺普罗斯 (Latanoprostene) 是一种可靠的药物.眼睛表面的表面是眼睛的表面.眼部表面疾病指数-得分指数.更多相关视频
相关概念视频
01:27Open Angle Glaucoma: Treatment
452
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
452
01:28Angle Closure Glaucoma: Treatment
500
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
500
01:25Glaucoma: Overview
573
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
573