接种COVID-19疫苗后的耳鼻喉学并发症,疫苗不良事件报告系统 (VAERS)
Jieun Shin1,2, Sung Ryul Shim1,2, Jaekwang Lee3
1Department of Biomedical Informatics, College of Medicine, Konyang University, Daejeon, Republic of Korea.
Frontiers in public health
|January 25, 2024
概括
接种COVID-19疫苗可以导致免疫接种后的耳鼻喉学不良事件 (AEFI),包括嗅觉和味觉功能障碍. 这项研究分析了AEFI数据,发现了与某些疫苗和人口因素相关的特定风险.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 报告显示,在COVID-19疫苗接种后,免疫接种后的耳鼻喉学不良事件 (AEFI),如嗅觉和味觉功能障碍.
- 分析这些AEFI对于了解疫苗安全概况至关重要.
研究的目的:
- 使用大规模数据分析COVID-19疫苗接种后的耳鼻喉学AEFI.
- 确定与这些AEFI相关的特定症状,发病率和风险因素.
主要方法:
- 疫苗不良事件报告系统 (VAERS) 和COVID-19数据追踪器的二次数据分析.
- 使用"监管活动医学词典" (MedDRA) 概念将AEFI分为19个主要类别.
- 根据年龄,性别和疫苗制造商分层计算的发病率 (IR) 和比例报告比率 (PRR).
主要成果:
- 在超过2.26亿个人中确定了106,653个耳鼻喉学AEFI.
- 完成的初级系列的总体IR为47.068/100,000,更新的双价增压器为7.237.
- 女性的AEFI显着更高;詹森疫苗对于 tinnitus 和 anosmia 等特定疾病的IR更高. 最高的PRR是厌氧,酸性反流和耳.
结论:
- 这一大规模分析提供了耳鼻喉科AEFI在COVID-19疫苗接种后的全面特征.
- 发现超越了事报告,提供了这些不良事件的坚实肖像.
- 结果有助于做出有关疫苗安全和监测的知情决策.
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