局部皮质类固醇用于治疗男孩的花病
Gladys Moreno1, Cristian Ramirez2, Javiera Corbalán3
1Department of Family Medicine, Evidence Based Health Care Program, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
The Cochrane database of systematic reviews
|January 25, 2024
概括
局部用皮质类固醇可以有效地治疗男孩的花症,增加完全和部分解脱率. 这种非侵入性治疗显示出有利的结果,副作用很少,尽管需要更多的研究.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 皮肤病学 皮肤病学
- 基于证据的医学基于证据的医学.
背景情况:
- 菲莫斯症,即无法收回前皮的情况,影响男孩,并经常通过手术治疗.
- 包括局部皮质类固醇在内的非侵入性治疗方法已经显示出有前途.
研究的目的:
- 评估局部皮质类固醇的疗效与安慰剂或没有治疗男孩的花病.
- 评估结果,如完全和部分分辨率,可收回性和不良影响.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 在多个数据库 (CENTRAL,MEDLINE,Embase,LILACS,ClinicalTrials.gov) 进行了搜索,截至2023年10月.
- 包括1459名参与者参加的14个RCT,使用风险比率和置信区间分析结果.
主要成果:
- 局部用皮质类固醇在4-8周后显著增加了菲莫सिस的完全解脱 (RR 2.73) 和部分解脱 (RR 1.68) (低确定性证据).
- 长期完全分辨率也增加了 (RR 4.09) (低确定性证据).
- 关于可伸缩性得分的影响存在不确定性;不良影响是最小的 (低确定性证据).
结论:
- 局部用皮质类固醇似乎有效治疗男孩的阴影症,改善解决率,不良事件的风险较低.
- 证据质量受到研究局限性和异质性的限制,需要进一步进行高质量的试验.
- 这种非手术方法为割礼或前皮造形提供了潜在的替代方案.
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