体重指数升高会影响传感运动到转移模式等级的脑状态动态
Jinfeng Han1, Kaixiang Zhuang2, Debo Dong1
1Key Laboratory of Cognition and Personality, Ministry of Education, Faculty of Psychology, Southwest University, Chongqing, China.
Obesity (Silver Spring, Md.)
|January 25, 2024
概括
较高的BMI会改变大脑活动状态,影响传感运动和转运系统. 这种改变的大脑状态的动态解释了肥胖,认知衰退和精神疾病症状之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 精神病学是一个精神病学.
背景情况:
- 超重和肥胖 (高BMI) 与大脑功能变化有关,可能导致认知和情绪问题.
- 与肥胖相关的特定大脑动态变化仍然不清楚.
研究的目的:
- 研究身体质量指数 (BMI) 如何影响大脑活动状态和动态.
- 探索BMI,大脑动态和功能结果 (如认知衰退和精神疾病) 之间的关系.
主要方法:
- 利用了来自两个大型独立数据集 (N=1923和N=998) 的静止状态功能磁共振成像 (fMRI) 数据.
- 采用隐藏马尔科夫模型来分析时空大脑活动状态.
- 检查了大脑状态动态的变化及其与BMI和功能结果的相关性,包括纵向数据验证.
主要成果:
- 增加的BMI将大脑活动转移到感觉运动系统状态,阻碍过渡到跨模态系统状态.
- 这些发现在一项纵向研究中得到证实,该研究显示BMI增加与大脑动态变化相关.
- 发现改变的大脑状态动态能够调解BMI与不良结果之间的关联,例如认知能力下降和精神疾病症状.
结论:
- 大脑状态动态中与肥胖有关的变化,特别是在感官运动到跨模态层次结构中,提供了新的见解.
- 这些发现有助于理解与肥胖有关的脑功能障碍和心理健康挑战背后的神经机制.
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