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针对I阶段双胞胎输血综合征的选择性胎镜激光疗法后长期神经发育结果

Angel Chimenea^1,2, Lutgardo García-Díaz^1,3, Guillermo Antiñolo^1,2,3,4

¹Department of Materno-Fetal Medicine, Genetics and Reproduction, Institute of Biomedicine of Seville, Hospital Universitario Virgen del Rocio/CSIC/University of Seville, Seville, Spain.

Clinical pediatrics

|January 25, 2024

概括

胎镜激光手术用于单胎怀孕的早期双胞胎输血综合征 (TTTS) 导致有利的神经发育结果. 这些结果与无并发症怀孕的结果相似,表明FLS对I期TTTS有效.

科学领域:

周围生理学周围生理学
胎儿医学胎儿医学
新生儿神经病学新生儿神经病学

背景情况:

单胞胎 (MC) 怀孕会面临诸如双胞胎输血综合征 (TTTS) 这样的并发症.
胎镜激光手术 (FLS) 是高级TTTS的标准,但其在Quintero I阶段TTTS的使用仍在争论中.
在FLS后早期TTTS的长期神经发育结果需要进一步调查.

研究的目的:

为了评估2年的神经发育结果,在治疗FLS治疗QuinteroI阶段TTTS的儿童中.
为了将这些结果与那些患有FLS治疗的高级TTTS的儿童和不复杂的单胆双胞胎双胞胎 (MCDT) 的儿童进行比较.

主要方法:

进行了一项观察性研究,涉及156名儿童.
参与者被分为三个组:第一阶段TTTS (n=14),高级TTTS (n=28) 和无并发性MCDT (n=114).
在2岁时进行了神经发育评估.

主要成果:

在I阶段TTTS组中,92.9%的患者表现出正常的神经发育,没有严重的神经障碍.
这些结果在统计学上与没有并发症的双胞胎组相似 (92.1%的神经发育正常,P = .921).
先进的TTTS组显示正常神经发育率 (89.3%) 不显著较低.

结论:

对于昆特罗I阶段TTTS的胎镜激光手术与有利的长期神经发育结果有关.
用FLS治疗的I阶段TTTS的结果与无并发症单胎怀孕的结果相似.
FLS似乎是早期TTTS的安全和有效的治疗选择,促进正常的神经发育.

关键词:

胎儿镜检查 (fetoscopy) 是一种对胎儿进行的检查.一种单胞胎双胞胎生长.神经发育的结果.第一个阶段:Quintero.双胞胎 - 双胞胎输血综合征

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