通过剪波超声波弹性成像评估的肠度预测了克罗恩病患者的疾病行为进展
Yu-Jun Chen1, Jin-Shen He2, Shan-Shan Xiong2
1Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Clinical and translational gastroenterology
|January 25, 2024
概括
剪波弹性图 (SWE) 可以预测克罗恩病 (CD) 的进展. 诊断时肠度较高 (SWE>12.75 kPa) 的患者更有可能患上严重疾病.
科学领域:
- 胃肠病学 胃肠病学
- 医疗成像医学成像
- 诊断性的超声波检查
背景情况:
- 克罗恩氏病 (CD) 缺乏可靠的疾病进展预测指标.
- 实时剪波弹性图 (SWE) 评估组织硬度,但其在CD中的作用尚未被探索.
- 目前的诊断方法需要改进,以预测CD的行为变化.
研究的目的:
- 调查SWE和其他超声波参数在诊断时对CD行为进展的预测值.
- 建立一个定量模型来预测CD患者疾病进展的风险.
主要方法:
- 对接受肠道超声波的130名CD患者 (B1表型) 的回顾性分析.
- 后续检查以确定病情进展为严格化 (B2) 或透性 (B3) 疾病.
- 考克斯回归和名图为风险预测而建立.
主要成果:
- 27名患者 (20.8%) 在平均33个月的随访期间进展.
- SWE是疾病进展的唯一独立预测因子 (HR1.08,P=0.001).
- 结合SWE的诺米图表实现了良好的预测性能 (AUC=0.792).
结论:
- 通过SWE测量的肠性独立预测克罗恩病的疾病行为进展.
- 在诊断时SWE>12.75 kPa的CD患者面临着进展到严格或透性疾病的更高风险.
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