血清炎症因子对预测与流感病毒和Omicron共同感染的影响

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Chengli Zhang¹, Wei Wang², Xianglin Luo²

¹Zigong First People's Hospital, Zigong Academy of Medical Sciences, Zigong, China.

Immunity, inflammation and disease

|January 25, 2024

概括

预白蛋白水平可以帮助区分单一和联合感染的流感和Omicron变体,帮助治疗决策. 将前白蛋白和CRP结合起来,可以提高共感染的诊断准确性.

科学领域:

传染性疾病传染性疾病
临床生物化学临床生物化学
病毒学病毒学

背景情况:

区分病毒单一感染和并发感染对于有效的患者管理至关重要.
流感病毒和SARS-CoV-2 (包括Omicron变种) 是常见的呼吸道病原体,可以同时发生.

研究的目的:

为了确定单一感染和与流感病毒和Omicron共感染之间的关键实验室指标差异.
评估前专辑蛋白和C反应蛋白 (CRP) 在区分这些感染中的诊断效用.

主要方法:

在患有SARS-CoV-2 (野生型),Omicron,流感A/B (流感A/B) 和流感A/B-Omicron联合感染的患者中分析前白蛋白和CRP水平.
利用接收器运行特征 (ROC) 曲线和物流回归来评估预测能力.

主要成果:

与单一感染患者相比,同时感染和野生型感染患者的CRP和前白蛋白水平显著不同 (p < .001).
在识别来自Omicron或流感A/B的共感染时,前专辑蛋白显示出比CRP更高的效率.
前白蛋白和CRP的联合预测显著改善了共感染与单一感染的区分 (AUC:0.934和0.887).

结论:

前专辑蛋白作为一个有价值的指标,用于检测并发感染和指导及时治疗.
结合前白蛋白和CRP预测提供了一个更有效的诊断工具,用于区分联合感染和单一感染.

关键词:

在C-反应性蛋白质中.这就是Omicron.流感病毒流感病毒在前专辑蛋白中,前专辑蛋白是预测并发感染的情况.

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