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对非洲猪瘟病毒基因组编码序列的代码使用模式的系统分析揭示了其宿主适应表型

Yuening Wang^1,2,3,4, Chenglin Chi^1,2,3,4, Jiajia Zhang^1,2,3,4

¹College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, PR China.

Microbial genomics

|January 25, 2024

概括

非洲猪瘟病毒 (ASFV) 显示了适度的密码使用偏差,受核酸组成和选择的影响. ASFV比猪更适应,这表明长期的共同进化.

科学领域:

病毒学病毒学
进化生物学进化生物学
基因组学就是基因组学.

背景情况:

非洲猪瘟 (ASF) 是一种破坏性病毒性疾病,影响着全球的猪群.
非洲猪瘟病毒 (ASFV) 导致猪业的高死亡率和重大经济损失.
了解ASFV的进化和宿主适应对于疾病控制至关重要.

研究的目的:

研究ASFV的进化动态和宿主适应.
分析编码子的使用模式,并确定影响它们的因素.
评估ASFV适应其宿主,包括子和家猪的情况.

主要方法:

64种ASFV菌株的遗传学分析 (邻居连接,最大概率).
在ASFV编码序列中对代码使用偏差 (CUB) 的分析.
评估诸如核酸组成,突变压力,选择和地理多样性等因素.
的适应指数 (CAI) 和相似性指数 (SI) 分析以评估宿主适应.

主要成果:

ASFV菌株被分为四个不同的分类.
ASFV表现出适度的编码子使用偏差.
核酸组成,突变压力,自然选择和地理来源影响ASFV的CUB.
与家猪相比,ASFV对软 (Ornithodoros moubata) 的适应性更高.

结论:

在ASFV中,子的使用模式是由多种进化和遗传因素塑造的.
观察到的适应差异表明ASFV和之间的长期共同进化关系.
这些发现增强了对ASFV的健康状况,进化和宿主相互作用的理解,为疾病管理策略提供了信息.

关键词:

非洲猪瘟病毒 (ASFV) 病毒科登偏差是指科登偏差.进化分析是一种进化分析.宿主适应能力宿主适应能力

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