根据地理和社会经济地位,型Dx测试和随后的化疗接收的差异
Sarah C Van Alsten1, Matthew R Dunn1, Alina M Hamilton2,3
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
概括
对早期乳腺癌的OncotypeDx基因组测试被黑人和低收入妇女所使用不足. 检测与化学疗法减少有关,特别是在低风险瘤中,突出显示了护理方面的差异.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 型Dx是一种基因组测试,用于早期HR+/HER2乳腺癌.
- 它指导辅助化疗决策.
- 在符合条件的患者中,测试的普及程度并不普遍.
研究的目的:
- 根据人口和地理情况,检查OncotypeDx测试的变化.
- 为了确定OncotypeDx测试是否与化疗接收有关.
- 确定影响测试差异的因素.
主要方法:
- 在卡罗莱纳州乳腺癌研究中对1615名HR+/HER2-,I-II期瘤妇女进行分析.
- 根据社会人口统计学因素测试的流行率差异估计.
- 评估测试,化疗和种族之间的关联.
- 测试率的评估根据县的农村,社会经济地位和区域因素.
主要成果:
- 38%的有资格的妇女接受了型Dx测试.
- 在黑人 (31%) 和低收入 (24%) 妇女中观察到较低的测试率.
- 城市参与者的测试率低于农村参与者的测试率.
- 在基因组风险较低的瘤中,被测试的女性接受的化疗减少了29%.
- 化学疗法的种族差异仅限于未经测试的女性.
结论:
- 个人和地区层面的社会经济因素显著预测OncotypeDx测试的可能性.
- 对基因组测试的不平等接入导致HR+/HER2-乳腺癌化疗使用的差异.
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K