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视网母细胞瘤的三维超声成像及其与病理学的相关性

Aparna Ramasubramanian, Monique Riemann, Alex Brown

Ophthalmic surgery, lasers & imaging retina

|January 25, 2024

概括

使用二维 (2D) 和三维 (3D) 超声波的客观瘤体积测量显示,与视网膜母细胞瘤的病理估计有很强的相关性. 这些定量指标可以作为评估视网膜母细胞瘤治疗反应的可靠替代品.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
在瘤学瘤学.

背景情况:

评估视网膜母细胞瘤治疗反应依赖于主观的方法,如底膜扫描和OCT.
需要客观的,定量化的瘤体积估计来评估器官保护疗法.
主要瘤体积为治疗反应提供了一个客观的替代品.

研究的目的:

评估2D和3D超声波瘤体积估计和视网膜母细胞瘤病理体积之间的相关性.
确定定量超声波指标作为视网膜母细胞瘤治疗反应的替代标记物的有用性.

主要方法:

追溯分析了12例经过核切除的视网膜母细胞瘤病例.
在去核之前进行了2D和3D超声波瘤体积测量.
超声波衍生的体积与黄金标准病理体积的比较.

主要成果:

两种2D和3D超声波瘤体积测量与病理估计有很强的相关性 (r=0.69,P=0.018;r=0.66,P=0.027).
用体积探针进行3D超声波测量是非常实用的,并考虑不规则的瘤形状.
超声波提供了对视网膜母细胞瘤瘤体积的客观,定量数据.

结论:

视网膜母细胞瘤原发性瘤体积的二维和三维超声波测量与病理发现高度相关.
3D超声波在评估不规则瘤形态方面具有优势.
需要进一步的研究来验证这些指标作为治疗反应的替代标记.

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