在COVID-19中胃肠道症状和疾病严重程度:一项基于日本注册的回顾性队列研究
Yuta Matsubara1, Hiroki Kiyohara2, Yohei Mikami1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan.
COVID-19患者的腹与需要重症监护或机械通风的可能性较低有关. 这表明腹可能表明2019年新冠肺炎疾病 (COVID-19) 的较温和形式.
科学领域:
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
- 临床医学 临床医学
背景情况:
- 之前关于胃肠道 (GI) 症状和2019年新冠肺炎疾病 (COVID-19) 严重程度的研究得出了不确定的结果.
- 了解胃肠道症状和COVID-19预后之间的相关性对于患者管理至关重要.
研究的目的:
- 调查胃肠道症状的存在与COVID-19患者的临床结果之间的关联.
- 为了澄清GI症状的预后意义在COVID-19严重程度的背景下.
主要方法:
- 一项回顾性队列研究使用来自日本全国COVID-19登记册的数据进行.
- 分析了2020年2月至2022年8月期间诊断的3498名住院和门诊COVID-19患者的数据.
- 用多变量调整后勤回归模型来评估GI症状和临床结果之间的关联.
主要成果:
- 腹,恶心/吐,腹痛和黑色素的患病率分别为16.6%,8.9%,3.5%和0.7%.
- 腹与重症监护室 (ICU) 入院的可能性显著降低 (aOR,0.70;95% CI,0.53 - 0.92) 和机械通风 (aOR,0.61;95% CI,0.42-0.89).
- 敏感性分析证实了这些发现,表明腹与严重的COVID-19结果的保护性关联.
结论:
- COVID-19患者的腹与更好的临床结果有关.
- 腹的存在可能是2019年冠状病毒疾病中不太严重的疾病过程的指标.
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