开发用于药物测试中的定量尿液分析的新矩阵参考材料
Min Lv1,2, Yujie Zhi1,2, Liying Zhou1
1Department of Forensic Toxicology, Shanghai Key Laboratory of Forensic Medicine, Academy of Forensic Science, No. 1347, Guangfu West Road, Putuo District, Shanghai, 200063, China.
Analytical and bioanalytical chemistry
|January 25, 2024
概括
开发冷干燥尿液参考材料 (RMs) 提高了实验室的分析准确性和质量控制. 这些稳定的RM为尿液分析提供了可靠的结果,改善了实验室过程.
科学领域:
- 临床化学 临床化学
- 分析化学 分析化学
- 实验室医学 实验室医学
背景情况:
- 在实验室中进行准确的定量分析需要标准化的过程控制和改进方法.
- 尿液参考材料 (RMs) 可以提高尿液分析的准确性并减轻矩阵效应.
- 开发可靠的RM对于一致的实验室诊断至关重要.
研究的目的:
- 详细说明尿液中矩阵参考材料的开发.
- 评估开发的尿液RMS的同质性,稳定性和不确定性.
- 为了验证冷干燥尿液RMs对质量控制的有用性.
主要方法:
- 为人类和猪尿样建立了冷干燥工艺.
- 评估了均性,稳定性 (在各种温度和条件下) 和不确定性.
- 通过使用开发的RMS测量真实尿样来评估量化可靠性.
主要成果:
- 经冷干燥的尿样显示出与液体样本相比的同质性.
- 在各种条件下,冷干燥的RM显示出比液体样本更高的稳定性.
- 人类尿液矩阵RM与尖样本提供一致的结果,表明其可靠性很高.
结论:
- 冷干燥尿液矩阵参考材料是实验室使用的稳定可靠工具.
- 这些RM适用于尿液分析的日常质量控制.
- 开发的RMS有助于提高实验室测试的准确性和标准化.
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