Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

988
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
988
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

De novo and comparative transcriptome analysis of cultivated and wild spinach.

Scientific reports·2015
Same author

Effect of Pixel's Spatial Characteristics on Recognition of Isolated Pixelized Chinese Character.

The open biomedical engineering journal·2015
Same author

Persistence of cirrhosis is maintained by intrahepatic regulatory T cells that inhibit fibrosis resolution by regulating the balance of tissue inhibitors of metalloproteinases and matrix metalloproteinases.

Translational research : the journal of laboratory and clinical medicine·2015
Same author

Effect of image registration on longitudinal analysis of retinal nerve fiber layer thickness of non-human primates using Optical Coherence Tomography (OCT).

Eye and vision (London, England)·2015
Same author

The PsychENCODE project.

Nature neuroscience·2015
Same author

Multiple magnetic relaxation processes, magnetocaloric effect and fluorescence properties of rhombus-shaped tetranuclear rare earth complexes.

Dalton transactions (Cambridge, England : 2003)·2015

相关实验视频

Updated: Jul 5, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

837

自动反应反应的评估.

Shuang Liu1

  • 1Department of Pharmacology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan. liussmzk@m.ehime-u.ac.jp.

Methods in molecular biology (Clifton, N.J.)
|January 25, 2024
PubMed
概括

研究人员开发了一种简单的方法来检测T细胞对II型原 (CII) 等自我抗原的反应,这种方法是在风湿性关节炎 (RA) 的小鼠模型中. 这有助于了解疾病的原因,并开发RA的新疗法.

科学领域:

  • 免疫学 免疫学 免疫学
  • 这是一种自身免疫力.
  • 类风湿病学 类风湿病学

背景情况:

  • 类风湿性关节炎 (RA) 的发病与自我容忍的丧失有关.
  • 识别自身抗原和自身反应性抗体有助于理解RA的病原性.
  • 像原这样的自我抗原与自身免疫反应有关.

研究的目的:

  • 引入一种简单的方法来评估T细胞对II型原蛋白 (CII) 的自身反应反应.
  • 阐明T细胞激活在小鼠原诱导性关节炎 (CIA) 模型中的作用.
  • 为评估T细胞对自身免疫性疾病中的特定抗原的反应提供一种工具.

主要方法:

  • 使用小鼠原蛋白诱导性关节炎 (CIA) 模型.
  • 建立一个限制稀释系统来量化T细胞反应.
  • 测量细胞因子释放作为CII依赖T细胞激活的指标.

主要成果:

  • 该方法成功估计了T细胞对CII.II的自身反应反应.
  • 细胞因子释放水平与CII特异性T细胞活性相关.
  • 这种方法可以阐明高亲和度T细胞受体依赖激活.
关键词:
自动反应反应的响应.原蛋白是一种原蛋白.由原诱导的关节炎淋巴细胞 淋巴细胞脊髓细胞 (splenocytes) 是一种细胞.

更多相关视频

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.1K
Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
09:04

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry

Published on: April 19, 2017

13.5K

相关实验视频

Last Updated: Jul 5, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

837
Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

7.1K
Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
09:04

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry

Published on: April 19, 2017

13.5K

结论:

  • 这种方法提供了一种简单的方法来研究T细胞在RA中的自身免疫性.
  • 了解T细胞对CII等自身抗原的反应对于RA研究至关重要.
  • 该技术可用于识别自身反应性T细胞,并为RA的治疗发展提供信息.