一个基于小组的跨诊断性睡眠和主要抑郁症的昼夜治疗:一个随机对照试验
Anneko Yuen-Yum Yau1, Ka-Yan Ng1, Wing-Yin Lau1
1Department of Psychology, Chinese University of Hong Kong.
Journal of consulting and clinical psychology
|January 25, 2024
概括
针对睡眠和昼夜功能障碍 (TranS-C) 的基于小组的干预有效地改善了患有严重抑郁症 (MDD) 的成年人的抑郁症状和睡眠质量. 这些好处在12周的随访中持续存在,这表明TranS-C是一种可行的治疗选择.
科学领域:
- 精神病学和睡眠医学
- 临床心理学 临床心理学
- 行为科学 行为科学
背景情况:
- 在严重抑郁症 (MDD) 中经常观察到睡眠和昼夜节律障碍.
- 解决这些睡眠和昼夜问题对于有效管理MDD至关重要.
- 现有的治疗方法可能无法完全解决MDD中并发性睡眠问题的复杂性.
研究的目的:
- 评估基于睡眠和昼夜功能障碍 (TranS-C) 的群体跨诊断干预措施的有效性.
- 评估TranS-C对MDD成年人的抑郁症状和睡眠/昼夜功能的影响.
- 为了确定TranS-C是否为这个人群提供比标准护理更好的优势.
主要方法:
- 一项随机对照试验,涉及152名患有MDD和睡眠/心律功能障碍的成年人.
- 参与者被分配到TranS-C干预组或通常护理 (CAU) 中.
- 评估包括抑郁,焦虑,睡眠,疲劳,生活质量和功能障碍在基线,治疗后和12周的随访.
主要成果:
- 与CAU组相比,TranS-C组在抑郁症状,失眠严重程度,睡眠障碍,疲劳和焦虑方面表现出显著的改善.
- 治疗后观察到生活质量和睡眠日记参数的显著改善.
- 在12周的随访期内,治疗效果保持不变,功能障碍明显改善.
结论:
- 在TranS-C干预是有效的,并被广泛接受,以减少抑郁症状和睡眠/循环节障碍的成年人患有MDD.
- 在TranS-C的小组格式中,提供了一个具有成本效益和可扩展的治疗选择.
- 建议进行进一步的研究,以探索TranS-C在其他精神疾病中的疗效.
相关概念视频
Management of Insomnia
250
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
250
Insomnia
86
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
Multiple factors contribute...
86
Sedatives and Hypnotics Drugs: Miscellaneous Agents
176
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
176
Antidepressant Drugs: MAOIs and Other Agents
234
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
234
REM Sleep Behavior Disorder
187
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
187
Understanding Sleep
228
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
228


