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Updated: Jul 5, 2025

Direct Reprogramming of Human Fibroblasts into Myoblasts to Investigate Therapies for Neuromuscular Disorders
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甲基马龙酸血症的脂质变化与FGF21升高和异常的甲基马龙化相关

Irini Manoli1, Justin R Sysol1, PamelaSara E Head1

  • 1Metabolic Medicine Branch, National Human Genome Research Institute.

JCI insight
|January 25, 2024
PubMed
概括

甲基马龙酸性血 (MMA) 导致独特的脂肪分布,类似于脂质营养不良. 小分子治疗在小鼠中诱导了有益的脂肪"beiging",这表明MMA患者的潜在治疗策略.

关键词:
氨基酸代谢 氨基酸代谢遗传学 是一个遗传学.鼠标模型 鼠标模型肥胖问题 肥胖问题治疗方法 治疗方法

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