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Updated: Jul 5, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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不匹配修复蛋白MLH1抑制了BRCA2缺乏乳腺瘤的复制性压力

Satheesh K Sengodan1, Xiaoju Hu2, Vaishnavi Peddibhotla1

  • 1Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland USA.

The Journal of clinical investigation
|January 25, 2024
PubMed
概括

失去BRCA2会导致细胞死亡,但MLH1过度表达可以使缺陷细胞存活. MLH1稳定复制叉,抑制基因组的不稳定性,帮助瘤的发展.

关键词:
乳腺癌是什么? 乳腺癌是什么?修复DNA的修复DNA的修复遗传的不稳定性 遗传的不稳定性遗传学 遗传学 是一个

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