相关实验视频

Updated: Jul 5, 2025

Flow Cytometric Characterization of Murine B Cell Development
08:25

Flow Cytometric Characterization of Murine B Cell Development

Published on: January 22, 2021

15.8K

Kidins220 调节带有 λ 轻链的 B 细胞的发育

Anna-Maria Schaffer1,2,3, Gina Jasmin Fiala1,2,3, Miriam Hils1,3,4

  • 1Faculty of Biology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.

eLife
|January 25, 2024
PubMed
概括

激酶D相互作用基质220kDa (Kidins220) 对于B细胞发育至关重要. 素220缺乏症通过影响Igl位点的可访问性和信号传递,损害了λ轻链B细胞的发育.

关键词:
B 细胞 B 细胞 B 细胞适应性免疫是一种适应性免疫.免疫学 免疫学 免疫学这是一种炎症炎症炎症炎症.兰巴达灯链灯链是什么意思这里是鼠标鼠标鼠标鼠标鼠标鼠标.再组合的复合方式.信号信号是指一个信号.

更多相关视频

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

18.4K
Recombinant Retroviral Production and Infection of B Cells09:19

Recombinant Retroviral Production and Infection of B Cells

Published on: February 18, 2011

14.2K

相关概念视频

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.4K