发现新酸衍生物作为杀菌剂候选物的新发现
Hanru Liu1, Chonglin Cai1, Xingjia Zhang1
1Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, China.
Journal of agricultural and food chemistry
|January 25, 2024
概括
新型的肉氧化被合成为强大的绿色杀菌剂. 几种化合物对关键植物病原体如Gaeumannomyces graminis var.显示出高效率. 三,瓦尔萨马利和Botrytis cinerea,其中一些性能优于商业杀菌剂.
科学领域:
- 农业化学 农业化学
- 有机合成 有机合成
- 植物病理学 植物病理学
背景情况:
- 自然产品衍生对于发现新型环保农药至关重要.
- 在植物中丰富的酸具有多样化的生物活性.
- 开发有效的抗真菌农业化学品对于作物保护至关重要.
研究的目的:
- 设计和合成新型肉氧化作为潜在的抗真菌剂.
- 评估它们的抗真菌活性,建立结构-活性关系,并阐明它们的作用机制.
主要方法:
- 一系列新型肉氧胺的合成.
- 针对植物病原菌的抗真菌活性查 (Gaeumannomyces graminis var. 其他). 三,瓦尔萨马利, Botrytis cinerea). 这种植物的种类有:
- 定量结构-活动关系 (QSAR) 分析和行动研究的初步机制.
主要成果:
- 化合物7i,7u,7v和7x显示≥90%的抑制作用对抗G. graminis var. 这里是Triticum.Triticum.
- 化合物7z和7n对V. mali (EC50=0.71微克/毫升) 和B. cinerea (EC50=1.41微克/毫升) 分别表现出强烈的活性.
- 化合物7z对果瓦尔萨瘤有100%的疗效,而7n对番茄上的灰菌有96%的控制,与博斯卡利德相似.
结论:
- 新型肉氧化具有作为有效农业杀菌剂的巨大潜力.
- QSAR分析为设计改进的抗真菌化合物提供了基础.
- 化合物7n的机制涉及破坏真菌细胞核和线粒体,可能通过抑制厄戈斯特醇生物合成.
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