在非小细胞肺癌中Rothia与更糟糕的生存率有关
Yamato J Takabe1, Emily Allen2, Lyla Allen2
1Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Nichols High School, Buffalo, New York; Yale University, New Haven, Connecticut.
The Journal of surgical research
|January 25, 2024
概括
在非小细胞肺癌 (NSCLC) 患者中发现了Rothia细菌. 虽然Rothia存在与更糟糕的生存相关,但它也表明瘤扩散较少和更有利的免疫微环境.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 癌症基因组学 癌症基因组学
背景情况:
- 微生物组显著影响癌症生物学.
- 关于微生物对非小细胞肺癌 (NSCLC) 患者结局的影响的研究有限.
- 假设:特定的微生物与NSCLC患者的存活率相关.
研究的目的:
- 研究特定微生物与NSCLC患者存活率之间的关系.
- 确定与NSCLC不同存活率相关的微生物特征.
主要方法:
- 来自癌症基因组图谱 (TCGA) 的647名NSCLC患者的分析.
- 使用R软件进行数据分析.
- 使用火山图谱分析来比较短期和长期幸存者之间的微生物丰富度.
主要成果:
- 在短期幸存者中,Rothia是丰富的;在长期幸存者中发现了Blastococcus,Leptospira和Haematobacter.
- 仅仅罗西亚的存在与整体存活率有关.
- 罗阳性NSCLC显示细胞增殖减少,分数变化较少,同源重组缺乏,细胞透增加.
- 罗西亚阳性瘤表现出CD8 T细胞,CD4 T细胞,单细胞和NK细胞的透率较高,以及强大的干扰素马反应和T细胞受体丰富.
结论:
- 带有Rothia的NSCLC与较差的存活率有关,但也具有有利的瘤特征.
- 罗西亚的存在与细胞增殖的减少和瘤免疫微环境的改善有关.
- 罗西亚与NSCLC死亡率的关联可能独立于其瘤特征.
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