在IVF失败后,子宫内授精有多成功? 一项针对551名女性的研究
Faisel Alorf1, Sanah Alani1, Naama Steiner2
1Obstetrics and Gynecology Department, McGill University, Montreal, Quebec, Canada.
Reproductive biomedicine online
|January 25, 2024
概括
在体外受精 (IVF) 失败后,子宫内授精 (IUI) 提供每周期5%的持续怀孕率. 捐赠精子增加了成功率,特别是在年轻女性,而老年女性可能会发现它效率较低.
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗方法 不孕症治疗方法
- 辅助生殖技术 辅助生殖技术
背景情况:
- 宫内授精 (IUI) 是一种常见的生育治疗方法.
- 在IUI失败后,体外受精 (IVF) 经常被追求.
- 在IVF失败后IUI的有效性尚未得到充分证实.
研究的目的:
- 为了确定先前在体外受精 (IVF) 失败的患者的子宫内授精 (IUI) 的成功率.
- 为了确定影响怀孕结果的因素,在IUI循环中,在IVF失败后进行IUI.
主要方法:
- 551名患者进行了992次IUI周期的回顾性队列研究.
- 分析怀孕结果 (正在进行的,临床的,积极的) 与患者人口统计和治疗史相关.
- 使用伴侣精子与捐赠精子的IUI成功率的比较.
主要成果:
- 每位患者的累积持续怀孕率是7.44% 在IUI周期后,试管婴儿失败后.
- 第一个IUI周期后持续怀孕率为4.72%.
- 显著更年轻的女性获得更高的怀孕率;捐赠精子的使用与怀孕的几率增加6.1倍有关.
结论:
- 在IVF失败后IUI后持续怀孕发生在每周期大约5%左右.
- 捐赠精子的成功率更高,特别是在年轻女性 (<40岁) 中.
- 对43岁以上的女性来说,试管婴儿失败后的IUI可能不太适合.
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