IFNL1 rs30461 多态性作为COVID-19严重程度的危险因素:一个横截面研究
Maha O Hammad1, Mahmoud M Alseoudy2, Asmaa M Borg3
1Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Cytokine
|January 25, 2024
概括
IFNL1 SNP (rs30461) 基因变异与严重COVID-19的风险增加有关,而干扰素-lambda-1/干扰素-29 (IFN-λ1/IL-29) 血清水平在轻度和重度病例之间没有差异.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 病毒学 病毒学
背景情况:
- 导致严重COVID-19结果的分子机制尚不清楚.
- 干扰素-lambda-1/干扰素-29 (IFN-λ1/IL-29),是一种III型干扰素,表现出强大的抗病毒特性.
- 关于IFN-λ1/IL-29及其相关遗传变异在COVID-19严重性中的作用的数据有限.
研究的目的:
- 调查血清IFN-λ1/IL-29水平与IFNL1单核酸多态 (SNP) rs30461与严重COVID-19之间的关联.
- 确定IFNL1变种是否预测患有严重COVID-19的风险.
主要方法:
- 一项涉及400名COVID-19患者 (262名轻度,138名重度) 的横截面研究.
- 在两组患者中测量血清IFN-λ1/IL-29水平.
- 使用RT-PCR和Taqman探针进行IFNL1SNP (rs30461) 的基因定型.
- 后勤回归分析,以检查IFNL1变种与严重COVID-19风险之间的关联.
主要成果:
- 在轻度和重度COVID-19患者 (P=0.993) 之间没有观察到血清IFN-λ1/IL-29水平的显著差异.
- 在组之间发现IFNL1 SNP (rs30461) 的基因型和等位基因频率的显著差异.
- IFNL1 SNP (rs30461) 的小G等位基因与严重COVID-19的显著更高风险相关 (OR:2.1,P≤0.001).
- 在多变量分析中,IFNL1 SNP (rs30461) 的A/G和G/G基因型是COVID-19严重程度的独立预测因素 (P<0.05).
结论:
- IFNL1 SNP (rs30461) 可能作为COVID-19严重程度的独立遗传风险因素.
- 在这种队列中,血清IFN-λ1/IL-29水平似乎与COVID-19严重程度无关.
更多相关视频
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
11.8K
05:53Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
10.1K
相关概念视频
Single Nucleotide Polymorphisms-SNPs
15.1K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.1K
Leaky Scanning
5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
RNA Splicing
56.4K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
56.4K
Non-LTR Retrotransposons
11.5K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.5K
