肠道微生物组,大脑网络和精神分裂症患者的症状严重程度之间的关系:调解分析
Liqin Liang1, Shijia Li2, Yuanyuan Huang3
1School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 511442, China.
NeuroImage. Clinical
|January 25, 2024
概括
肠道微生物组和大脑网络与精神分裂症症状严重程度有关. 特定的肠道细菌,如Sellimonas,通过大脑网络变化影响症状,揭示了三方关系.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 微生物组-肠-大脑轴 (MGBA) 在精神分裂症 (SZ) 中至关重要.
- 关联肠道微生物群,大脑网络和SZ症状严重程度的机制尚不清楚.
- 了解这些相互作用对于SZ神经病理学至关重要.
研究的目的:
- 研究肠道微生物组,大脑网络和精神分裂症症状严重程度之间的三方关系.
- 为了确定SZ症状的特定微生物和神经相关物.
主要方法:
- 收集了38名SZ患者和38名对照者的便样本,MRI数据和PANSS分数.
- 使用16S rRNA基因测序分析了肠道微生物组.
- 从结构和功能MRI数据计算大脑网络节点属性.
- 构建调解模型来评估相互作用.
主要成果:
- 发现肠道微生物群和大脑网络之间存在强烈的相关性 (r=0.89,FDR校正后p<0.05).
- 精神分裂症症状严重程度 (PANSS分数) 与肠道微生物群 (r=0.5,FDR校正p<0.05) 和大脑网络 (r=0.59,FDR校正p<0.05) 相关.
- 塞利莫纳斯属的丰富度通过白质网络中心在下额头环和杏仁体中介 PANSS 负值.
- 19个调解模型显示大脑区域 (视觉,语言,动作控制系统) 与肠道微生物组调解PANSS分数.
结论:
- 建立了肠道微生物组,大脑网络和精神分裂症症状严重程度之间的三方关系.
- 突出了特定肠道细菌和大脑网络特性在SZ神经病理学中的作用.
- 建议在MGBA内针对精神分裂症的潜在治疗点.
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