从Cuphea carthagenensis中分离出来的埃拉基坦宁的血管松作用
Kaori Katiuska Yamaguchi Isla1, Mirtes Midori Tanae1, Maria Teresa Riggio de Lima-Landman1
1Department of Pharmacology, Section of Natural Products, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Planta medica
|January 25, 2024
概括
库菲亚carthagenensis水性提取物 (AE) 降低了老鼠的血压. 孤立的基坦宁通过氧化 (NO) 引起血管松,但它们的低生物可用性表明其他代谢物对体内低血压效应负责.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 心血管研究研究心血管研究
背景情况:
- 在巴西的民间医学中,Cuphea carthagenensis因其低血压作用而被使用.
- 植物提取物表现出中枢神经系统的抑郁性质.
- 这项研究调查了传统使用C. carthagenensis的科学基础.
研究的目的:
- 为了验证Cuphea carthagenensis水性提取物 (AE) 在老鼠中的低血压效应.
- 为了研究从AE中分离出来的特定埃拉基坦宁 (oenothein B,woodfordin C,eucalbanin B) 的血管作用.
- 阐明提取物及其成分对血压调节的作用机制.
主要方法:
- 非侵入性的尾巴手套方法来测量未经麻醉的老鼠的缩血压.
- 在实验室研究中,使用大动脉环和小鼠门静脉制剂来评估血管松和收缩反应.
- 用AE,分离的基素,诺亚上腺素,N-nitro-l-arginine甲基和CaCl2.2治疗.
主要成果:
- 口服C.carthagenensis AE诱导了与剂量相关的低血压效应在正常血压的老鼠.
- 隔离的基宁在先前收缩的大动脉环中引起了度依赖的血管松.
- 血管松是由内皮细胞的氧化 (NO) 合成/释放介导的,而不是通过改变血管光滑肌肉中的Ca2+流入.
结论:
- 这项研究证实了C. carthagenensis AE在老鼠中的低血压作用.
- 隔离的基坦宁通过一种依赖NO的机制促进血管松.
- 埃拉基坦宁的低口服生物可用性表明,它们的代谢物,而不是母化合物,可能是观察到的体内低血压效应的原因.
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