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母亲食用海鲜与改善状态有关:对儿童健康的影响

Nicholas V C Ralston¹, Laura J Raymond², Christy L Gilman³

¹Earth System Science and Policy, University of ND, Grand Forks, ND 58202, USA.

Neurotoxicology

|January 25, 2024

概括

孕妇在怀孕期间食用海洋鱼可以提高 (Se) 水平,保护胎儿发育免受甲基 (CH3Hg) 毒性的影响. 从鱼类中增加的Se摄入量超过了的风险,确保正常的大脑功能和发育.

科学领域:

环境毒理学和人类健康
营养生物化学和胎儿发育

背景情况:

(Se) 对于合成氨基 (Sec) 至关重要,氨基是参与胎儿发育,大脑功能和抗氧化剂防御的必要酶的组成部分.
甲基 (CH3Hg) 暴露无可逆地通过结合Sec来抑制酶,可能会损害神经发育,特别是在有限的Se储备的胎儿中.
人们对来自海鲜的孕产妇CH3Hg暴露存在担忧,但鱼类通常含有比CH3Hg更高的Se,这表明Se的保护作用.

研究的目的:

调查假设,母亲食用海洋鱼可增加胎儿的Se状态,从而防止CH3Hg诱导的抑制酶活性.
评估母亲的海鲜摄入量与胎儿组织中的 (Hg) 和 (Se) 水平之间的关系.

主要方法:

从夏威夷的100名新生儿身上收集了带血液和胎盘组织.
在怀孕的最后一个月,通过食物频率调查评估了母亲的海洋鱼的饮食摄入量,将消费分类为没有,低,高.
在母体和胎儿样本中测量Hg和Se度.

主要成果:

母亲的海鲜消费增加了胎儿的Hg水平,大约34%的带血样本超过了EPA对Hg的参考水平.
然而,胎儿组织中的Se度明显高于Hg水平.
海洋鱼类的消费导致带血Se比Hg增加了9.4倍,这表明净阳性Se平衡.

结论:

典型的海洋鱼的母体摄入量提供了大量的Se,有效地防止对Hg依赖的Se生物可用性损失,并支持胎儿发育.
鱼类中的Se:Hg比率至关重要,这表明食用富含Se的鱼类可以减轻与Hg暴露相关的潜在神经发育风险.
这项研究支持海鲜消费对胎儿健康的益处,澄清了复杂的Hg:Se关系,并协调了早期研究的相互矛盾的发现.

关键词:

这是带血.水星水星水星水星水星海洋鱼是海洋中的鱼.胎盘胎盘胎盘胎盘怀孕怀孕怀孕怀孕海鲜海鲜海鲜海鲜海鲜是一种.

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