一个对地形影响细胞迁移的随机模型
A J Mitchinson1, M Pogson2, G Czanner3
1School of Computer Science and Mathematics, Liverpool John Moores University, Liverpool, L3 3AF, United Kingdom.
Journal of theoretical biology
|January 25, 2024
概括
一个新的数学模型预测了各种地形上的细胞迁移模式. 奥恩斯坦-乌伦贝克工艺模型准确地预测NIH3T3纤维细胞在平面和线性表面的行为,有助于生物材料设计.
科学领域:
- 生物物理学的生物物理.
- 计算生物学 计算生物学
- 材料科学 材料科学 材料科学
背景情况:
- 细胞迁移对于生理功能至关重要,并且在生物材料和生物植入物中具有应用.
- 预测不同地形上的细胞迁移模式对于设计有效的生物材料至关重要,但目前的模型稀疏.
- 现有的模型往往侧重于细胞矩阵相互作用或形态反应,忽视迁移模式预测.
研究的目的:
- 提出和验证一种数学模型,用于预测不同2D地形上的单个细胞迁移模式.
- 评估模型在同位素 (平面) 和异位素 (线性,无序) 表面上预测迁移的能力.
- 将模型预测与NIH3T3纤维细胞迁移的实验数据进行比较.
主要方法:
- 开发了一个基于奥恩斯坦-乌伦贝克过程的细胞迁移数学模型.
- 应用该模型来模拟在均的平面,均的线性 (可变的山脊密度) 和非均的无序地形上的迁移.
- 与NIH3T3纤维细胞迁移实验数据集对比的校准模型输出.
主要成果:
- 该模型准确地预测了平面和线性地形上的迁移模式.
- 模型的预测与实验NIH3T3纤维细胞迁移非常相匹配,显示了脊柱密度的线性增加和中间密度的最佳速度.
- 探索结果表明,迁移模式可以适应混乱的地形,在线性模式中适度的扭曲可能不会阻碍方向指导.
结论:
- 一个基于奥恩斯坦-乌伦贝克的模型可以有效地预测NIH3T3纤维细胞迁移在同otropic和异otropic (线性) 地形.
- 该模型通过预测细胞迁移反应来指导生物材料和生物植入物设计.
- 需要进一步的研究,以有信心地预测复杂的,不统一的混乱的地形安排上的迁移模式.
相关概念视频
01:09Cell Migration
17.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.0K
01:21Chemotaxis and Direction of Cell Migration
3.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.4K
01:32Cytoskeletal Coordination in Cell Migration
4.8K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.8K
01:13Actin Polymerization and Cell Motility
5.3K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.3K
01:21Cell Polarization by Rho Proteins
2.7K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
2.7K
01:18Role of Myosin in Cell Migration
2.3K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.3K