在帕金森病患者中,直接刺激下丘脑核会影响发言和语音质量
Marine Bobin1, Neil Sulzer2, Gina Bründler2
1Cognitive and Affective Neuroscience Unit, University of Zürich, 8050 Zürich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland.
Brain stimulation
|January 25, 2024
概括
亚thalamic核 (STN-DBS) 的深度大脑刺激可以改善帕金森病 (PD) 患者的言语和声音. 最佳的结果取决于精确的刺激参数,特别是对右侧刺激,以增强声道功能.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 语音语言病理学 语言病理学
背景情况:
- 脑下核深度大脑刺激 (STN-DBS) 有效地治疗帕金森病 (PD) 运动症状.
- 然而,它对言语 (失声症) 和声音 (失声症) 的影响是不一致的,一些研究报告了负面影响.
研究的目的:
- 研究STN-DBS对PD患者的言语和语音质量的手术内影响.
- 为了确定最佳的刺激参数 (深度,横向性,强度) 来改善声乐症状.
主要方法:
- 在STN-DBS手术期间评估38名PD患者的言语和声音质量.
- 亚体内核的各种刺激参数 (深度,横向性,强度).
- 利用感知和声学分析进行客观和主观评估.
主要成果:
- 正确的STN-DBS显示了一些语音和语音症状的改善.
- 左侧和右侧STN-DBS都改善了脱节性语言;只有右侧STN-DBS改善了失声症.
- 在特定的STN子区域内,在低到中等强度时发生了最佳刺激.
结论:
- STN-DBS可以显著提高PD的语音和语音质量.
- 仔细调整刺激参数,特别是横向性和强度,对于最大限度地提高效益并最大限度地减少不良影响至关重要.
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