使用肠道内镜检测胃癌的检测率与血清风险分层:一个随机对照试验
Chika Kusano1, Takuji Gotoda2, Hideki Ishikawa3
1Department of Gastroenterology, Kitasato University School of Medicine, Kanagawa, Japan.
Gastrointestinal endoscopy
|January 25, 2024
概括
这项研究发现,每年检查和风险分层内镜之间胃癌检测率没有差异. 然而,风险分层方法显著增加了仅通过内镜切除可治愈的胃癌率.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 公共卫生查 公共卫生查
背景情况:
- 开发有效的胃癌 (GC) 查是至关重要的.
- 在ABC分类中,使用血清学标志物对GC风险进行了分层.
- 将风险分层纳入查可以优化早期检测和治疗.
研究的目的:
- 为了比较每年检查和风险分层内镜间隔之间的胃癌检测率.
- 评估不同查策略对检测到的胃癌治愈能力的影响.
主要方法:
- 一个为期5年的随机对照试验,涉及1206名参与者.
- 两个组:Ba-Endo (每年检查) 和ABC-Endo (基于ABC风险分类的内镜间隔).
- 用于基于性别和年龄的随机化最小化方法.
主要成果:
- 总体而言,GC检测率为1.9% (24病变).
- 在Ba-Endo (2.0%) 和ABC-Endo (1.8%) 组之间,GC检测率没有显著差异.
- 在ABC-Endo组 (90.9%) 与Ba-Endo组 (41.6%) 相比,单独通过内切除可治愈的GC率显著更高.
结论:
- 在这两种查策略之间,胃癌检测率相似.
- 风险分层内镜 (ABC-Endo) 显著改善了适应内镜切除的早期胃癌的比例.
- 基于GC风险分层的个性化查间隔,有望改善治疗结果.
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