性别特异性对外部化问题的脆弱性:对早期压力的敏感性和青春期的Accumbens核激活
Lauren R Borchers1, Justin P Yuan1, Josiah K Leong2
1Department of Psychology, Stanford University, Stanford, California.
Biological psychiatry
|January 25, 2024
概括
早期的压力敏感性会影响青春期内核聚集体 (NAcc) 激活轨迹. 降低NAcc激活与男孩的外部化问题有关,这表明心理病理学的性别特异性标志物.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 早期生活压力 (ELS) 增加了青春期精神病理的风险.
- 之前的研究表明,ELS. 激活了麻木的核 (NAcc) 激活.
- 与ELS相关的NAcc激活的发展轨迹仍未得到充分研究.
研究的目的:
- 调查ELS和压力敏感性如何影响青少年发育期间的NAcc激活轨迹.
- 检查生物性别在NAcc轨迹和精神病理学之间的关系中所起的调节作用.
主要方法:
- 在173名青少年 (9-18岁) 的长度研究中,进行了3次评估.
- 在基线评估目标ELS和应激灵敏度.
- 在评估中使用货币激励延迟任务来测量NAcc激活.
- 使用"青年自我报告"评估外部化,内部化和总体问题.
主要成果:
- 心理病理的症状在整个青春期都增加了.
- 压力敏感性,而不是客观的ELS,与NAcc激活轨迹的下降相关.
- 生物学性别调节了NAcc轨迹对心理病理学的预测;减少NAcc激活预测了男孩的更多外化问题.
结论:
- NAcc激活轨迹可以作为青少年外部化问题的性别特异生物标志物.
- 降低压力敏感性可以减轻精神病理症状,特别是在青少年男孩中.
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