神经成像生物标志物用于精神分裂症中药物发现和开发
Katrin H Preller1, Joachim Scholpp2, Andreas Wunder2
1Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany; Boehringer Ingelheim (Schweiz) GmbH, Basel, Switzerland.
Biological psychiatry
|January 25, 2024
概括
神经成像通过帮助目标发现和剂量选择来推进精神分裂症药物开发. 然而,对于有效治疗认知和负面症状,仍然需要验证的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 精神分裂症影响1%的人口,对认知和负面症状治疗的需求尚未得到满足.
- 神经成像研究正在推动对精神分裂症病理生理学和药物点的理解.
- 已验证的生物标志物至关重要,但目前缺乏用于新疗法开发.
研究的目的:
- 审查神经成像在治疗精神疾病的临床药物开发中的作用.
- 突出神经成像对目标发现,参与和剂量选择的贡献.
- 讨论神经成像生物标志物在药物开发中的潜力和局限性.
主要方法:
- 审查当前的神经成像技术及其在药物开发中的应用.
- 检查案例研究,例如NMDA受体低功能的目标.
- 对健康志愿者和患者群体中药理学神经成像的分析.
主要成果:
- 神经成像对于药物开发计划中的目标发现,参与和剂量选择至关重要.
- 药理神经成像可以为概念验证研究中的早期决策提供响应生物标志物.
- 患者群体中的生物标志物评估是有限的,在验证方面存在持续的挑战.
结论:
- 神经成像在促进治疗精神分裂症和相关疾病的药物开发方面发挥着至关重要的作用.
- 需要进一步的研究和验证,以建立可靠的神经影像生物标志物用于临床使用.
- 在未来,新的神经成像方法可能会使预测性,个性化的生物标志物成为可能.
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