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Updated: Jul 4, 2025

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

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LRP11通过MAPK13介导的TCF1酸化促进干状T细胞,增强抗PD1免疫疗法

Lingjuan Sun1, Zhibo Ma1, Xiangli Zhao1

  • 1Institute of Organ Transplantation，Tongji Hospital, Tongji Medical College; Key Laboratory of Organ Transplantation; Ministry of Education, NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Science, Huazhong University of Science and Technology, Wuhan, China.

Journal for immunotherapy of cancer
|January 25, 2024
PubMed
概括

低密度脂蛋白 (LDL) 通过LRP11和MAPK13激活TCF1+CD8+T细胞,增强抗瘤免疫力. 这一途径促进了类似干细胞的T细胞,这对于有效的免疫疗法反应至关重要.

关键词:
药物治疗,组合治疗.免疫检查点抑制剂 免疫检查点抑制剂免疫治疗是一种免疫疗法.淋巴细胞,瘤透细胞

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