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在伦理相关的热威胁期间,安全学习的前额调节

Ada C Felix-Ortiz¹, Jaelyn M Terrell¹, Carolina Gonzalez¹

¹Department of Neuroscience, Developmental, and Regenerative Biology, The University of Texas at San Antonio, San Antonio, Texas 78249.

|January 25, 2024

概括

小鼠学会了避开寒冷的威胁区,接近温暖的安全区. 中间前额皮层 (mPFC) 活动,特别是前额皮层 (PL) 和下额皮层 (IL) 区域,双向调节安全记忆形成.

科学领域:

神经科学是一个神经科学.
行为科学行为科学
学习和记忆的学习和记忆

背景情况:

威胁和安全学习对于生存至关重要.
中间前额叶皮层 (mPFC),包括前额叶 (PL) 和下额叶 (IL) 亚区域,参与威胁和安全处理.
在自然热挑战期间对威胁和安全的监管仍然不清楚.

研究的目的:

调查mPFC的PL和IL分区域在自然热条件下如何调节威胁和安全学习.
开发一种新的模式来研究基于空间的热威胁和安全记忆.
阐明PL和IL活动在这些记忆的形成和调节中的作用.

主要方法:

开发了一种新的鼠标范式,将视觉空间线索与有害的寒冷 (威胁) 或愉快的温暖 (安全) 温度联系起来.
评估了长期的避免 (威胁) 和接近 (安全) 行为,没有强化.
在记忆形成过程中利用光遗传学操纵PL和IL区域的神经活动.

主要成果:

小鼠很快就学会了,并对热威胁和安全区形成了持久的基于空间的记忆,分别表现出回避和接近的行为.
在PL和IL中神经活动对于建立威胁记忆并非必不可少.
PL和IL活动双向调节安全记忆;IL促进了安全记忆,而PL抑制了它,特别是在压力后.

结论:

PL和IL之间的平衡活动有利于安全记忆的形成.
特别是在压力后,PL和IL之间的不平衡活动会损害安全记忆.
一个工作模型表明,最佳的安全内存依赖于协调的mPFC子区域功能.

关键词:

行为灵活性行为灵活性带状皮层 (Cingulate cortex) 是一种带状皮层.冲突冲突冲突冲突恐惧恐惧恐惧恐惧在寻找寻找寻找寻找社会隔离,社会隔离.

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