情绪干预可以改善炎症性肠病中的炎症生物标志物吗? :一个系统的审查和元分析
Natasha Seaton1, Joanna Hudson1, Sophie Harding1
1Institute of Psychology Psychiatry and Neuroscience, King's College London, UK.
EBioMedicine
|January 25, 2024
概括
在炎症性肠病 (IBD) 中针对情绪的干预措施对炎症生物标志物和情绪显示出显著的益处. 心理疗法在减少炎症方面表现最为显著.
科学领域:
- 胃肠病学 胃肠病学
- 心理神经免疫学 心理神经免疫学
- 临床心理学 临床心理学
背景情况:
- 肠-大脑轴和心理神经免疫机制与炎症性肠病 (IBD) 活动有关.
- 以前的审查表明,心理治疗对自我报告的IBD活动没有影响.
- 这一元分析研究了情绪向干预措施对IBD炎症的影响.
研究的目的:
- 确定解决情绪结果 (抑郁,焦虑,压力) 的干预措施是否可以降低炎症性肠病 (IBD) 的炎症水平.
- 确定这些干预措施对炎症影响的潜在调节者.
主要方法:
- 对28项随机对照试验 (RCT) 的系统审查和元分析,涉及1789名参与者,遵守PRISMA指南.
- 纳入标准:针对情绪结果和评估IBD成年人的炎症标志物的RCT.
- 使用标准化平均差异 (SMD) 进行数据合成,随机效应强大的差异估计,以考虑多个生物标志物.
主要成果:
- 干预表明对炎症生物标志物有很小但显著的影响 (SMD = -0.35) 和对情绪结果的中等影响 (SMD = -0.50).
- 具体分析显示了便calprotectin (SMD = -0.19) 和C反应蛋白 (SMD = -0.29) 的小影响.
- 对心理治疗和干预措施观察到更大的影响,这些干预措施对情绪有显著影响.
结论:
- 针对情绪的治疗对一般炎症和特定IBD生物标志物,如便calprotectin和C-reactive protein,产生积极影响.
- 心理干预和那些具有更大的情绪益处的人对炎症标志物产生了增强的影响.
- 需要进一步的研究来阐明潜在的生物或行为机制.
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