氧化在狼怀孕和孕前的风险
Amadeia Rector1, Ivana Marić1, Yashaar Chaichian1
1Stanford University School of Medicine, Stanford, California.
Arthritis & rheumatology (Hoboken, N.J.)
|January 25, 2024
概括
氧化 (HCQ) 在患有全身性红斑狼 (SLE) 的孕妇中没有降低孕前风险. 这项研究没有发现统计学关联,强调需要在更大,基于人口的队列中进行进一步研究.
科学领域:
- 产科和妇科 产科和妇科
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 系统性红斑狼 (SLE) 不成比例地影响生育年龄的女性.
- 基氨酸 (HCQ) 是SLE的标准一线治疗.
- 孕前会影响到三分之一的SLE妇女怀孕.
研究的目的:
- 调查怀孕早期使用氧化 (HCQ) 是否降低了系统性红斑狼 (SLE) 患者的孕前风险.
主要方法:
- 在1020名私人保险的SLE患者中,对1068例单独怀孕的回顾性研究 (2007-2016).
- HCQ治疗被定义为从怀孕前到头三个月的处方填充.
- 用修改的波桑回归和倾向得分调整来分析按平价分层的风险比率 (RRs).
主要成果:
- 在约15%的怀孕中发生了孕前症.
- 在52%的怀孕中记录了HCQ的使用,并且与更多的并发症和SLE活动有关.
- 在经过调整后,在无孕 (RR 1.09) 或多胎 (RR 1.01) 怀孕中,没有发现HCQ使用和降低孕前风险之间的统计学关联.
结论:
- 这项保险数据库研究没有发现证据表明,使用HCQ可以降低孕妇SLE患者的孕前风险.
- 不能排除剩余的混和错误分类.
- 需要进一步的前性研究,使用更大规模的基于人口的数据,以澄清HCQ在孕前风险中的作用.
更多相关视频
12:02Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
Published on: July 30, 2016
15.9K
09:04Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
9.7K
相关概念视频
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
287
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
287
Antihypertensive Drugs: Thiazide-Class Diuretics
639
Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
639
