大型抑郁症与面部处理网络有效连接的相关变化:系统性审查
Alec J Jamieson1, Christine A Leonards2, Christopher G Davey2
1Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia. alec.jamieson@unimelb.edu.au.
Translational psychiatry
|January 25, 2024
概括
大型抑郁症 (MDD) 改变了大脑的连接. 患有MDD的个体显示,负面面孔的背侧前额叶皮与杏仁核的连接性减少,而快乐面孔的前额叶皮与杏仁核的连接性增加.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 大型抑郁症 (MDD) 的特点是情绪处理发生变化,特别是面部表情.
- 关于MDD在情绪处理过程中的有效连接性的神经成像研究,由于方法异质性,产生了不一致的结果.
研究的目的:
- 系统地审查和综合有关MDD在情绪面部表情处理过程中的有效连接差异的发现.
- 为了确定在MDD中改变大脑网络相互作用的一致模式.
主要方法:
- 在五个主要数据库 (PsycINFO,EMBASE,PubMed,Scopus,Web of Science) 进行了系统的搜索.
- 一个预先注册的协议 (CRD42021271586) 指导了研究选择.
- 分析了符合纳入标准的17项研究,以确定有效的连接差异.
主要成果:
- 患有MDD的参与者在处理负面面部表情时,表现出背侧前额皮层 (dlPFC) 与杏仁体的连接性减少.
- 患有MDD的个体在快乐的面部表情处理过程中显示出抑制性中腹前额皮层 (vmPFC) 与杏仁体的连接性增加.
- 杏仁体和前带皮层 (ACC) 之间的连接差异经常被注意到,但在研究中缺乏一致性.
结论:
- 在MDD中,改变有效连接的一致模式涉及与情绪价值相关的特定前额桃体路径.
- 需要进一步的研究来澄清杏仁体-ACC连接性变化的确切性质和次区域特异性.
- 调查与治疗反应相关的连接性的纵向变化可以揭示MDD的治疗机制.
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