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Updated: Jul 4, 2025

In vitro Reconstitution of the Active T. castaneum Telomerase
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2.7 Å 人类端粒酶H/ACA核糖蛋白的冷-EM结构

George E Ghanim1, Zala Sekne1, Sebastian Balch1

  • 1MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

Nature communications
|January 25, 2024
PubMed
概括

这项研究揭示了人类端粒酶和ACA (H/ACA) 盒子核糖蛋白 (RNP) 的高分辨率结构,揭示了新的分子相互作用. 这有助于我们更好地理解与端粒酶相关的疾病和RNA伪化机制.

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