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鉴定了一种新型的围 - 脑下垂体区域投射的血清神经系统,可以抑制先天的恐慌和有条件的恐惧反应
Cristian S Bernabe1,2,3, Izabela F Caliman4, Aline R R de Abreu5
1Department of Anatomy, Cellular Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA. cbernabe@iu.edu.
Translational psychiatry
|January 25, 2024
概括
背部和中间拉菲核中的血清素 (5-HT) 神经元作为恐慌和恐惧电路,通过抑制特定的下丘脑神经元来调节焦虑和恐惧行为.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经药理学神经药理学
背景情况:
- 血清素 (5-HT) 系统对于调节焦虑和创伤相关疾病至关重要.
- 与先天的恐慌和恐惧网络联系的神经传递神经传递的神经机制尚未得到充分理解.
- 围区域 (PFA) 的素 (OX) /谷氨酸神经元是恐慌和恐惧反应的关键.
研究的目的:
- 为了研究血清素 (5-HT) 输入从拉菲核到PFA在恐慌和恐惧行为中的作用.
- 在体内阐明这些血清激素突发的电路特异性功能.
主要方法:
- 通过光刺激PFA的谷类质神经元,在老鼠中诱导类似恐慌的反应.
- 逆行追踪 (霍乱毒素B) 用于识别激活PFA的5-HT神经元群体.
- 选择性化学遗传病变和纤维刺激的5-HT投射到PFA.
- 二氧化碳挑战与窒息相关的恐慌和恐惧调节范式.
主要成果:
- 对PFA的5-HT投射的选择性损伤加剧了对CO2和恐惧调节的类似恐慌反应.
- 在PFA中激发5-HT纤维减弱了CO2诱导的恐慌行为和条件化的位置偏好.
- 这些发现确定了一个特定的5-HT电路调节恐惧和恐慌.
结论:
- 从背部 (lwDRN) 和中间 (MRN) 拉菲核的侧翼向PFA投射的血清能神经元构成一个恐慌/恐惧电路.
- 这种电路也可能在调节奖励行为方面发挥作用.
- 针对这种电路可以为焦虑和创伤相关疾病提供新的治疗策略.
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