青光眼治疗的坚持与疾病进展和对随访的丧失之间的关联
Laura Oltramari1, Steven L Mansberger2, Júlia Mendonça Ponte Souza1
1Hospital Oftalmológico de Brasília, Brasília, Brazil.
Scientific reports
|January 25, 2024
概括
近30%的初级开角格劳科马患者表现出较低的药物坚持,影响了疾病的进展和随访. 在这项拉丁美洲研究中,年龄较小和收入较低等因素与不良遵守有关.
科学领域:
- 眼科医生 眼科 眼科
- 公共卫生 公共卫生
背景情况:
- 对控制眼内压力和预防视力丧失至关重要.
- 药物事件监测系统 (MEMS) 提供客观的遵守数据,但拉丁美洲的研究有限.
研究的目的:
- 在巴西患者中使用MEMS评估青光眼治疗的坚持性,患者患有初级开角青光眼 (POAG).
- 为了将坚持率与1年后的青光眼进展和跟踪损失 (LTF) 相对应.
- 为了确定与不良粘附相关的因素.
主要方法:
- 一项前性队列研究,包括使用眼部低血压眼滴的110名POAG患者.
- 通过MEMS监测了60天的坚持,低坚持定义为服用的处方剂量的<75%.
- 通过使用光眼治疗合规性评估工具 (GTCAT) 探索了坚持,临床/人口统计变量,光眼进展和LTF之间的相关性.
主要成果:
- 28.18%的患者表现出较低的坚持.
- 不良坚持与青光眼的进展,LTF,年龄较小,教育/收入较低,缺乏医疗保险,疾病持续时间和峰值眼内压力有关.
- GTCAT构造也与坚持率相关联.
结论:
- 在巴西,很大一部分POAG患者表现出不良的药物坚持.
- 坚持与疾病进展和LTF等临床结果有关,突出显示了针对性干预的必要性.
- 这项研究提供了第一个基于MEMS的对拉丁美洲青光眼的坚持数据,确定了不坚持的关键风险因素.
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