德克斯梅德托米丁与埃托米达结合对接受全静脉麻醉的老年患者手术后认知功能的影响:一项随机,双盲,受控试验
Wuchang Fu1, Hongchun Xu2, Ting Zhao3
1The Second Clinical Medical college of North, Sichuan Medical College (Nanchong Central Hospital), Nanchong, 637000, China.
BMC geriatrics
|January 25, 2024
概括
德克斯梅德托米丁与埃托米达麻醉剂相结合,可以改善老年患者的认知功能. 这种组合可以减少术后认知功能障碍,焦虑和抑郁,同时降低特定的生物标志物.
科学领域:
- 麻醉学 麻醉学
- 老年医学 老年医学
- 神经科学是一个神经科学.
背景情况:
- 埃托米达因其血液动力学稳定性而被青用于老年和重症患者的麻醉.
- 德克斯梅德托米丁表现出神经保护和抗炎作用,有可能减轻老年人手术后认知功能障碍.
研究的目的:
- 调查结合埃托米达和德克斯梅德托米丁对老年患者术后认知功能的影响.
- 评估在使用这种药物组合时不同的麻醉持续时间对认知结果的影响.
主要方法:
- 132名接受尿管透镜霍尔激光光治疗的老年患者被随机分为埃托米达-诺库伦 (EN) 和埃托米达-德克斯米达-埃托米丁 (ED) 组.
- 患者进一步分为短期 (≤1小时) 和长期 (>1小时) 手术子组.
- 认知功能主要使用迷你精神状态检查 (MMSE) 进行评估,次要结果包括焦虑,抑郁,镇静得分,记忆回忆和特定蛋白质生物标志物 (S-100β,NSE).
主要成果:
- 埃托米达特 - 德克斯米达特米丁 (ED) 组的MMSE得分明显高于埃托米达特 - 诺库伦 (EN) 组.
- 与EN组相比,ED组的抑郁症 (ZSDS),状态特征焦虑 (S-AI) 和特征焦虑 (T-AI) 的得分较低.
- 接受埃托米达特-德克斯梅德托米丁治疗的患者表现出更好的记忆回忆和较低的S-100β和NSE血度,特别是在长期手术小组中.
结论:
- 德克斯梅德托米丁的使用,当与埃托米达麻醉相结合时,有效地改善老年患者的术后认知功能.
- 这种组合疗法可以缓解出现的激动,抑郁和焦虑,同时还可以减少关键的神经炎症标志物 (S-100β,NSE).
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