内脏脂肪和通用焦虑障碍 (GAD) 之间的关联
Ghazaleh Nameni1, Shima Jazayeri2, Masoud Salehi3
1Department of Nutrition, School of Public Health, Iran University of Medical Sciences , Tehran, Iran.
BMC psychology
|January 25, 2024
概括
内脏脂肪与女性的泛性焦虑症 (GAD) 有关,较高的脂肪指标与增加的GAD患病率相关. 在男性中没有发现任何显著的关联,这表明在GAD发育中存在性别特异关系.
科学领域:
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 通用焦虑症 (GAD) 与炎症增加有关.
- 了解炎症媒介对于新型GAD治疗至关重要.
- 内脏脂肪组织 (VAT) 在炎症途径中发挥作用.
研究的目的:
- 为了研究内脏脂肪组织 (VAT) 和GAD之间的关系.
- 评估GAD与内脏脂肪指数 (VAI),内脏脂肪面积 (VFA),体重指数 (BMI) 和腰围 (WC) 的相关性.
- 在伊朗员工健康队列研究 (EHCSIR) 中,分析男性和女性的这些关联.
主要方法:
- 在EHCSIR研究 (2017-2020) 中,分析了3889名参与者 (年龄大于18岁) 的数据.
- 使用复合国际诊断面试 (CIDI-2.1) 评估终身和12个月的GAD.
- 用STATA中的逻辑双项回归计算GAD和各种肥胖度的调整流行率 (PR) 的计算.
主要成果:
- 在女性中,与VFA相关的12个月GAD患病率较高 (PR: 1.42).
- 肥胖女性 (BMI >30) 的终身GAD患病率较高 (PR: 2.35).
- 女性增加的VAI与更长寿命的GAD相关 (PR:1.25).
- 在男性中,增加的VFA与较低的终身GAD患病率相关 (PR:0.65).
结论:
- 内脏脂肪性与女性GAD患病率有积极的关联.
- 在男性中,VFA和GAD症状之间没有发现显著的关系.
- 这些发现突出了内脏脂肪在GAD中的作用的潜在性别差异.
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