重编程自然杀手细胞用于癌症治疗
Kexin Wang1, Linqin Wang1, Yiyun Wang1
1Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China; Liangzhu Laboratory, Hangzhou, Zhejiang Province, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang Province, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang Province, China.
概括
自然杀手 (NK) 细胞疗法为癌症治疗提供了CAR-T细胞疗法的替代方案. 本综述探讨了增强NK细胞有效性,持久性和瘤向性的策略,以改善免疫治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 化学抗原受体 (CAR) -T细胞疗法显示出希望,但面临诸如毒性和产品可变性等挑战.
- 自然杀手 (NK) 细胞正在被探索为替代免疫疗法,因为它们的独特特性和"现成"产品的潜力.
研究的目的:
- 审查目前抗瘤NK细胞治疗的临床试验.
- 提供对重新编程NK细胞以增强其抗瘤功能的创新策略的概述.
- 讨论改善癌症治疗的潜在组合疗法.
主要方法:
- 审查目前涉及NK细胞治疗的临床试验.
- 探索基因编辑技术和组合方法来增强NK细胞功能.
- 分析改善NK细胞持久性,细胞毒性,贩运和克服瘤微环境的能力的策略.
主要成果:
- 包括未经编辑和重新编程的细胞在内的NK细胞治疗已经显示出对瘤的早期有效性迹象.
- 正在探索先进的基因编辑和组合策略,以克服NK细胞的局限性.
- 改善NK细胞持久性,细胞毒性,贩运和免疫逃避是关键的研究领域.
结论:
- NK细胞为CAR-T细胞疗法提供了一个有前途的替代方案,具有"现成"应用的潜力.
- 创新策略对于增强NK细胞抗瘤活性和克服目前的局限性至关重要.
- 对基因编辑和组合疗法的进一步研究将推动基于NK细胞的癌症免疫疗法.
相关概念视频
01:27Cytotoxic T Cells-mediated Immune Response
917
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
917
01:28Cells of the Innate Immune Response
1.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K
01:27Tumor Immunotherapy
526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:14Introduction to Nuclear Reprogramming
1.9K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
1.9K