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比菲多细菌通过调节肠道免疫来改善小鼠雌激素缺乏引起的骨质疏松症
Jincan Zhang1, Xi Liang2, Xiaoying Tian3
1College of Food Science and Engineering, Ocean University of China, Qingdao 266000, China. zhanglanwei@ouc.edu.cn.
Food & function
|January 26, 2024
概括
像Bifidobacterium这样的益生菌可以通过减少肠道炎症和调节肠道微生物群来改善骨密度,并减少骨质疏松症的骨损失. 这些发现为未来的益生菌疗法提供了对肠骨轴的新见解.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 骨质疏松症是一个日益严重的健康问题,特别是在老年人群中.
- 肠道微生物群和免疫系统都与骨代谢有关.
- 益生菌影响骨质疏松症的确切机制尚不清楚.
研究的目的:
- 为了研究Bifidobacterium菌株对卵巢切除小鼠模型骨质疏松症的影响.
- 探索Bifidobacterium对肠道免疫力和肠道微生物群组成的影响.
- 阐明益生菌介导的骨健康改善背后的机制.
主要方法:
- 对抗炎症特性进行Bifidobacterium菌株 (B. bifidum FL228.1,B. animalis F1-7) 的查.
- 构建一个被卵巢切除的小鼠模型来模拟骨质疏松症.
- 评估骨矿物质密度 (BMD),骨结构,肠道炎症标志物和肠道微生物群组成.
主要成果:
- 治疗Bifidobacterium显著改善了骨质量,骨体积/总体积 (BV/TV) 和状骨数 (Tb·N),抑制了骨损失.
- 益生菌干预减少了肠道炎症性细胞因子,并保护了粘膜屏障的完整性 (occludin,ZO-1,claudin-2,MUC2).
- 特定菌株调节了肠道微生物群:B. bifidum FL228.1增加了有益细菌,而B. animalis F1-7改变了Bifidobacterium,Desulfovibrio和Ruminococcus的丰富性.
结论:
- 双杆菌菌株通过调节肠道免疫力和保护肠道屏障,有效地减轻骨质疏松症.
- 这些益生菌降低了亲炎性M1巨细胞,并影响特定的肠道细菌群.
- 这项研究为通过肠-骨轴开发针对性益生菌治疗骨质疏松症提供了基础.
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