在越南进行了增强剂COVID-19疫苗混合后的抗体反应
Tram Hong Tran1, Hung Van Pham1, Thien Huu Doan1
1National Institute for Control of Vaccines and Biologicals, Ministry of Health, 100000 Hanoi, Vietnam.
Discovery medicine
|January 26, 2024
概括
提升剂COVID-19疫苗对于维持抗体水平至关重要. 在初始剂量后混合AstraZeneca和Pfizer疫苗,与其他组合相比,导致抗体度更高,不良事件更少.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 增剂疫苗对于对SARS-CoV-2的持续抗体反应至关重要.
- 了解不同疫苗组合的免疫性对于公共卫生战略至关重要.
研究的目的:
- 为了评估在COVID-19增剂接种疫苗后的抗体反应.
- 为了比较各种疫苗组合策略的免疫性.
主要方法:
- 一项涉及越南河内679名成年人的横截面研究.
- 参与者接受了两剂阿斯特拉泽内卡,瑞或莫德纳疫苗.
- 测量了SARS-CoV-2 S1/S2 IgG抗体的度.
主要成果:
- mRNA疫苗 (Moderna,Pfizer) 引起的IgG水平比AstraZeneca更高.
- 与同类药物Pfizer或AstraZeneca相比,混合AstraZeneca和Pfizer的IgG升高的几率更高.
- 阿斯特拉泽内卡-瑞混合体显示抗体水平比同类疫苗增加.
结论:
- 同源的mRNA疫苗比DNA载体疫苗更具有免疫性.
- 与同类疫苗相比,阿斯特拉泽内卡-瑞联合疫苗的抗体水平更高,不良事件更少.
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