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Updated: Jul 4, 2025

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
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胆酶抑制剂相关的胸部脱节/QT延长:一个现实世界的药监测研究

Ni Zhang1, Lanlan Gan1, Guiyuan Xiang1

  • 1Department of Pharmacy, Daping Hospital, Army Medical University, Chongqing, China.

Frontiers in pharmacology
|January 26, 2024
PubMed
概括

用于阿尔茨海默病的胆酶抑制剂 (ChEIs) 显示出与QT延长和TdP的强烈联系. 这种风险在老年妇女和治疗的最初一个月内更高,特别是在某些药物组合中.

关键词:
公平的人是公平的.胆化酶抑制剂 胆化酶抑制剂药物安全 药物安全药监测研究研究药监测研究扭伤的点/QT延长

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
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Cholinergic Antagonists: Pharmacokinetics

Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations,  while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
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Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers

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Class I antiarrhythmic drugs are used to treat various types of arrhythmias or irregular heart rhythms. These drugs block the sodium (Na+) channels in the cardiac cells, thereby affecting the movement of electrical impulses across the heart. Class I antiarrhythmic drugs are divided into three subgroups: Class IA, Class IB, and Class IC, each with distinct mechanisms of action and effects on the heart.
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