来自非洲药用植物的库马林的生物活性和毒性
Godwin Anywar1, Emmanuel Muhumuza1
1Department of Plant Sciences, Microbiology and Biotechnology, College of Natural Sciences, Makerere University, Kampala, Uganda.
Frontiers in pharmacology
|January 26, 2024
概括
非洲药用植物产生的各种库马林具有显著的生物活性,包括抗微生物和抗癌特性. 然而,这些天然化合物也表现出各种毒性,需要进一步研究安全的治疗应用.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
背景情况:
- 库马林是天然存在的植物和微生物代谢物,在食品和药物行业广泛使用.
- 它们表现出广泛的生物活性,包括抗炎,抗,抗瘤,抗微生物和抗凝固特性.
研究的目的:
- 评估来自非洲药用植物的库马林的生物活性和毒性概况.
- 确定具有潜在治疗应用的特定氨酸,并评估与之相关的风险.
主要方法:
- 在线数据库 (PubMed,Google Scholar,Web of Science) 的综合文献搜索,用于库马林研究.
- 包括1956年至2023年期间以英语出版的全篇研究文章.
- 系统审查和分析已识别的库马林,它们的植物来源,以及报告的生物活性和毒性.
主要成果:
- 从15种非洲植物物种中鉴定出22种库马林,其中北非的度显著.
- 抗微生物活性是最常见的 (46.7%),其次是五种特定库马林的抗瘤/抗癌特性 (osthole,伪 Kordatolide C & calanolide, chartreusin, esculetin).
- 六种库马林表现出一系列的毒性,包括抗凝剂作用,细胞毒性,神经毒性,肝和光毒性以及致癌潜力.
结论:
- 非洲药用植物是生物活性库马林的丰富来源,具有多种治疗潜力.
- 鉴定的毒性强调了在广泛临床使用之前严格进行安全性和疗效研究的必要性.
- 需要进一步的研究,以利用这些氨酸的好处,同时减轻相关风险.
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