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通过高吞吐量脂酶A2查平台优化毒蛇毒的药物发现

Laura-Oana Albulescu1,2, Adam Westhorpe1,2, Rachel H Clare1,2

  • 1Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Frontiers in pharmacology
|January 26, 2024
PubMed
概括

研究人员开发了一种高通量药物选器,以寻找新的脂酶A2 (PLA2) 抑制剂,用于治疗蛇中毒. 这种方法选了成千上万种药物,识别出新型化合物来对抗毒毒性并预防严重的病理.

关键词:
发现药物的发现.高通量选的高通量选被忽视的热带疾病蛇毒是一种蛇毒.蛇咬伤带来的毒药.毒素抑制剂 毒素抑制剂

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