烟草使用者的氧化剂和抗氧化剂状况:一个横截面研究
Pallavi Chauhan1, Sujatha S Reddy2, Vasudha K Chokkanna3
1Oral Medicine and Radiologist, Private Practitioner, Meerut, Uttar Pradesh, India.
National journal of maxillofacial surgery
|January 26, 2024
概括
与对照组相比,使用烟草显著增加了氧化应激,这表明使用者体内有较高的甲 (MDA) 水平和较低的抗氧化酶活性 (超氧化解氧化酶和谷氨过氧化酶).
科学领域:
- 生物化学 生化学
- 氧化压力研究研究 氧化压力研究
- 戒烟科学 戒烟科学
背景情况:
- 烟草的使用,无论是吸烟还是无烟,都会增加氧化应激和脂质过氧化.
- 马隆迪甲基 (MDA) 是脂质过氧化的一个关键标记物.
- 抗氧化酶,如谷氨过氧化酶 (GPx) 和超氧化脱氧化酶 (SOD),对于防御氧化损伤至关重要.
研究的目的:
- 为了量化烟草使用者的马隆迪阿尔海德 (MDA) 水平.
- 测量抗氧化酶超氧化脱氧化酶 (SOD) 和谷氨过氧化酶 (GPx) 在烟草使用者的活性.
- 为了比较烟草使用者和非使用者之间的这些生化标志物.
主要方法:
- 一项病例对照研究涉及30名无烟烟草使用者,30名吸烟者和30名对照者.
- 血清MDA水平使用硫巴比特酸法进行测量.
- 使用Ransel抗氧化剂套件确定了血清SOD和GPx活动.
主要成果:
- 在所有吸烟者中,血清MDA水平都较高,而无烟吸烟者与吸烟者相比,MDA水平显著更高.
- 与对照组相比,吸烟者和无烟烟草使用者的血清SOD和GPx水平降低了.
- 增加烟草使用的持续时间和频率与较高的MDA和较低的SOD/GPx水平相关.
结论:
- 生物化学标志物MDA,SOD和GPx反映了烟草使用者的氧化剂-抗氧化剂平衡.
- 这些标记可以帮助患者教育,并激励戒烟干预措施.
- 了解这些生化变化对于解决烟草使用带来的公共卫生危机至关重要.
相关概念视频
01:11Observational Studies
8.6K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
8.6K
01:25Statistical Methods for Analyzing Epidemiological Data
366
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
366
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:20Radical Autoxidation
2.1K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.1K