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Updated: Jul 4, 2025

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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伊米因还原酶的计算设计:机制引导的立体选择性逆转和接口稳定

Kai Wu1, Jinrong Yan2,3, Qinde Liu1,4

  • 1School of Pharmacy, Shanghai University of Medicine & Health Sciences 279 Zhouzhu Highway, Pudong New Area Shanghai 201318 China shaolei00@gmail.com.

Chemical science
|January 26, 2024
PubMed
概括

研究人员设计了imine还原酶 (IREDs) 以实现精确的性胺合成. 计算设计在关键的药物中间体中实现了反向立体选择性和增强的稳定性.

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