转激素由微生物上调调节,并作为免疫的负调节剂,诱导肠道免疫耐受性
Xiaopeng Tang1,2, Mingqian Fang1, Ruomei Cheng1
1Engineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), and Sino-African Joint Research Center, New Cornerstone Science Institute, Kunming Institute of Zoology, the Chinese Academy of Sciences, No.17 Longxin Road, Kunming, Yunnan, 650201, China.
共生微生物促进肠道转移素,一种免疫抑制剂,通过抑制模式识别受体信号传递,促进肠道耐受性. 这种机制对于维持肠道平衡和免疫耐受性至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 主体-微生物相互作用,特别是铁交换,对于肠道平衡和免疫耐受性至关重要.
- 控制这些交叉对话的机制及其对免疫耐受性的影响仍然在很大程度上是未知的.
研究的目的:
- 阐明细菌产品在调节宿主转激素中的作用及其在免疫耐受性中的功能.
- 为了研究转激素在胃肠道疾病中的治疗潜力.
主要方法:
- 使用无细菌小鼠,小鼠结肠炎模型和非人类灵长类动物研究.
- 研究的细菌产品诱导了转激素上调及其与CD14的相互作用.
- 评估了转激素补充和转激素-CD14阻断对免疫反应的影响.
主要成果:
- 细菌产品上调宿主转移素,该转移素通过抑制模式识别受体 (PRR) 通过CD14发出信号来抑制免疫反应.
- 降低的转激素水平与无菌小鼠和性结肠炎患者的免疫耐受性受损相关.
- 转林补充剂在小鼠中改善了结肠炎,并在患有慢性腹的子中表现出治疗效果.
结论:
- 结合性细菌通过调节转激素来促进肠道耐受性,这会抑制PRR信号传递,并抵消自我诱导的免疫激活.
- 转基因是治疗胃肠道炎症的潜在治疗点.
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